Pathology & Laboratory Medicine

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Faculty Publications

Recently Added Publications:

The complexity of the serine glycine one-carbon pathway in cancer.

Maria Teresa Diaz-Meco Conde, PhD, Jorge Moscat, PhD

The complexity of the serine glycine one-carbon pathway in cancer.

J Cell Biol. 2020 Jan 6;219(1).

Reina-Campos M, Diaz-Meco MT, Moscat J.

PMID: 31690618

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Serrated Colorectal Cancer: The Road Less Travelled?

Jorge Moscat, PhD

Serrated Colorectal Cancer: The Road Less Travelled?

Trends Cancer. 2019 Nov;5(11):742-754.

Nakanishi Y, Diaz-Meco MT, Moscat J.

PMID: 31735291; PMCID: PMC6894428

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The Dual Roles of the Atypical Protein Kinase Cs in Cancer

Maria Teresa Diaz-Meco Conde, PhD, Jorge Moscat, PhD

The Dual Roles of the Atypical Protein Kinase Cs in Cancer

Cancer Cell. 2019 Sep 16;36(3):218-235. 

Reina-Campos M, Diaz-Meco MT, Moscat J.

PMID: 31474570; PMCID: PMC6751000

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HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells

Tan Ince, MD, PhD

HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells

Oncogene. 2019 Sep;38(39):6599-6614.

Caslini C, Hong S, Ban YJ, Chen XS, Ince TA.

PMID: 31375747

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Ovarian Cancer Treatment Stratification Using Ex Vivo Drug Sensitivity Testing

Tan Ince, MD, PhD

Ovarian Cancer Treatment Stratification Using Ex Vivo Drug Sensitivity Testing

Anticancer Res. 2019 Aug;39(8):4023-4030.

Lohse I, Azzam DJ, Al-Ali H, Volmar CH, Brothers SP, Ince TA, Wahlestedt C.

PMID: 31366484

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Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.

Maria Teresa Diaz-Meco Conde, PhD

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.

Cancer Cell. 2019 Mar 18;35(3):385-400.

Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K, Beltran H, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT.

PMID: 30827887; PMCID: PMC6424636

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Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

Jorge Moscat, PhD

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

Cancer Cell. 2019 Mar 18;35(3):385-400.

Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K, Beltran H, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT.  

PMID: 30827887; PMCID: PMC6424636

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Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance

Jorge Moscat, PhD

Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance

Immunity. 2018 Dec 18;49(6):1132-1147.e7.

Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J.

PMID: 30552022; PMCID: PMC6301096

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Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells

Tan Ince, MD, PhD

Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells

Clin Cancer Res. 2018 Oct 1;24(19):4874-4886. 

Simpkins F, Jang K, Yoon H, Hew KE, Kim M, Azzam DJ, Sun J, Zhao D, Ince TA, Liu W, Guo W, Wei Z, Zhang G, Mills GB, Slingerland JM.

PMID: 29959144; PMCID: PMC6557165

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Metabolic reprogramming of the tumor microenvironment by p62 and its partners

Maria Teresa Diaz-Meco Conde, PhD

Metabolic reprogramming of the tumor microenvironment by p62 and its partners

Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):88-95.

Reina-Campos M, Shelton PM, Diaz-Meco MT, Moscat J.

PMID: 29702207; PMCID: PMC6193563

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Label and Immobilization Free Detection and Differentiation of Tumor Cells

Tan Ince, MD, PhD

Label and Immobilization Free Detection and Differentiation of Tumor Cells

IEEE Sensors Journal: Volume: 18 , Issue: 9 , May, 1 2018

Gajasinghe R, Jones M, Ince TA and Tigli O.

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The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

Jorge Moscat, PhD

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

Cell Rep. 2018 Apr 24;23(4):1178-1191.

Shelton PM, Duran A, Nakanishi Y, Reina-Campos M, Kasashima H, Llado V, Ma L, Campos A, García-Olmo D, García-Arranz M, García-Olmo DC, Olmedillas-López S, Caceres JF, Diaz-Meco MT, Moscat J.

PMID: 29694894; PMCID: PMC5958623

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Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor

Maria Teresa Diaz-Meco Conde, PhD, Jorge Moscat, PhD

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor

Cancer Cell. 2018 Apr 9;33(4):770-784.

Huang J, Duran A, Reina-Campos M, Valencia T, Castilla EA, Müller TD, Tschöp MH, Moscat J, Diaz-Meco MT.

PMID: 29634950; PMCID: PMC5896786

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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

Jorge Moscat, PhD

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

Cancer Cell. 2017 Dec 11;32(6):824-839.

Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M.

PMID: 29153842; PMCID: PMC5730340

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ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma

Maria Teresa Diaz-Meco Conde, PhD, Jorge Moscat, PhD

ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma

Cell Metab. 2017 Dec 5;26(6):817-829.

Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT.

PMID: 28988820; PMCID: PMC5718961

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Metabolism shapes the tumor microenvironment

Maria Teresa Diaz-Meco Conde, PhD

Metabolism shapes the tumor microenvironment

Curr Opin Cell Biol. 2017 Oct;48:47-53. 

Reina-Campos M, Moscat J, Diaz-Meco M.

PMID: 28605656; PMCID: PMC5650101

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Sphingolipids: Fats That Protect The Heart

Annarita Di Lorenzo, PhD

Sphingolipids: Fats That Protect The Heart

Scientia. Sep 13, 2017
Di Lorenzo A.
http://www.scientia.global/dr-annarita-di-lorenzo-sphingolipids-fats-protect-heart/

SciPod. October 2017
Di Lorenzo A.
http://www.scipod.global/sphingolipids-fats-that-protect-the-heart-dr-annarita-di-lorenzo-cornell-university/

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Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma

Tan Ince, MD, PhD

Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4184-E4192. 

Alekseyenko AA, Walsh EM, Zee BM, Pakozdi T, Hsi P, Lemieux ME, Dal Cin P, Ince TA, Kharchenko PV, Kuroda MI, French CA.

PMID: 28484033; PMCID: PMC5448232

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Modeling complex cancer rearrangement landscapes

Marcin Imielinski, MD, PhD

Modeling complex cancer rearrangement landscapes

Current Opinion in Systems Biology. 2016 Dec 26 [Epub ahead of print]

Maciejowski  J, Imielinski M. 

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Insertions and Deletions Target Lineage-Defining Genes in Human Cancers

Marcin Imielinski, MD, PhD

Insertions and Deletions Target Lineage-Defining Genes in Human Cancers

Cell. 2017 Jan 26;168(3):460-472.

Imielinski M, Guo G, Meyerson M.

PMID: 28089356

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