Laboratory of Neoplastic Hematopoiesis

Principal Investigator: 
Anna (Seung Ha) Nam, M.D.

The Nam Lab seeks to decipher the genotype-to-phenotype relationships in neoplastic blood development. In particular, we recognize that somatic mutations alone do not fully explain cancer phenotypes and seek to define the non-genetic modulators of disease states. For example, our work in myeloproliferative neoplasms demonstrated that the transcriptional impact of somatic mutations varies as a function of cell identity. Thus, our goal is to understand how non-genetic modifiers of somatic mutation impact (such as cell identity, epigenetics and microenvironment) may dictate disease states and patient outcomes. Our lab focuses on developing single-cell multi-omics technologies and computational algorithms to address these questions directly in human hematopoiesis. In this way, we reveal fundamental concepts of tumorigenesis and evolution, as well as identify specific therapeutic targets for translational impact.

Active Projects

  • Modulation of hematopoietic stem cells and microenvironment through cytokine signaling
  • Clonal hematopoiesis and determinants of malignant transformation
  • Lineage plasticity as a mode of therapy resistance

Grants

PI: Anna (Seung Ha) Nam, M.D.
National Institutes of Health (NIH) Early Independence Award

PI: Anna (Seung Ha) Nam, M.D.
Burroughs Wellcome Fund Career Awards for Medical Scientists 

PI: Anna (Seung Ha) Nam, M.D.
STARR Cancer Consortium

PI: Anna (Seung Ha) Nam, M.D.
STARR Cancer Consortium

Lab Team

Laboratory of Neoplastic Hematopoiesis Team

Additional Key Academic Personnel

Sara Moein
Research Associate
sam4032@med.cornell.edu
Mirca Saras Saurty-Seerunghen
Post Doc
mss4006@med.cornell.edu

Photo Gallery

Contact Information

Anna Nam, M.D.
Assistant Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College

1300 York Ave
C440
New York, NY 10065
Phone: 
212-746-9180

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700