Laboratory of Epigenetics and Genomic Integrity

Principal Investigator: 
Jessica K. Tyler, Ph.D.

Dr. Tyler’s laboratory focuses on discovering the mechanistic basis of the epigenetic regulation of aging, genomic integrity and gene expression. Our studies use a combination of molecular genetics in budding yeast, tissue culture studies, biochemistry and next generation sequencing approaches. The proteins and processes that we study are so fundamentally conserved through eukaryotic evolution, that we can take advantage of the strengths of the highly genetically malleable yeast system to guide our studies in human cells. In addition to learning how chromatin regulates fundamental processes in the cell, our studies are helping us to understand how defects in the chromatin structure lead to gene dysfunction and genomic instability, in turn causing aging and disease states including cancer.

Jessica Tyler Lab Photo

Active Projects

  • Role of chromatin structure in maintaining genomic stability
  • Attaining longevity via chromatin dynamics
  • Discovering the mechanism of chromatin assembly

Grants

PI: Jessica Tyler, Ph.D.
National Institutes of Health (NIH) Research Grant

PI: Jessica Tyler, Ph.D.
National Cancer Institute (NIH)

PI: Jessica Tyler, Ph.D.
National Institutes of Health (NIH) Research Grant

Lab Team

Laboratory of Epigenetics and Genomic Integrity Team

Additional Key Academic Personnel

Ujani Chakraborty
Post Doc
ujc4001@med.cornell.edu
Zulong Chen
Post Doc
zuc2001@med.cornell.edu
Juan Gutierrez Alvarez
Post Doc
jig2015@med.cornell.edu
Chitra Mohan
Post Doc
chm4006@med.cornell.edu
Spike Postnikoff
Post Doc
sdp2004@med.cornell.edu

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700