Laboratory of Epigenetics and Genomic Integrity

Principal Investigator: 
Jessica K. Tyler, Ph.D.

Dr. Tyler’s laboratory focuses on discovering the mechanistic basis of the epigenetic regulation of aging, genomic integrity and gene expression. Our studies use a combination of molecular genetics in budding yeast, tissue culture studies, biochemistry and next generation sequencing approaches. The proteins and processes that we study are so fundamentally conserved through eukaryotic evolution, that we can take advantage of the strengths of the highly genetically malleable yeast system to guide our studies in human cells. In addition to learning how chromatin regulates fundamental processes in the cell, our studies are helping us to understand how defects in the chromatin structure lead to gene dysfunction and genomic instability, in turn causing aging and disease states including cancer.

Jessica Tyler Lab Photo

Active Projects

  • Role of chromatin structure in maintaining genomic stability
  • Attaining longevity via chromatin dynamics
  • Discovering the mechanism of chromatin assembly

Grants

PI: Jessica Tyler, Ph.D.
National Institutes of Health (NIH) Research Grant

PI: Jessica Tyler, Ph.D.
National Cancer Institute (NIH)

PI: Jessica Tyler, Ph.D.
National Institutes of Health (NIH) Research Grant

PI: Jessica Tyler, PhD
National Institutes of Health (R13 grant)

PI: Jessica Tyler, PhD
National Institutes of Health (R43 SBIR subaward)

PI: Jessica Tyler, PhD
National Institutes of Health (R01 grant)

Lab Team

Laboratory of Epigenetics and Genomic Integrity Team

Additional Key Academic Personnel

Ujani Chakraborty
Post Doc
ujc4001@med.cornell.edu
Juan Gutierrez Alvarez
Research Associate
jig2015@med.cornell.edu

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