Vascular and Sphingolipid Biology

Principal Investigator: 
Annarita Di Lorenzo, Ph.D.

Dr. Di Lorenzo’s laboratory is interested in two major area of research: one is to define the molecular mechanisms by which endothelial nitric oxide synthase (eNOS)-derived NO controls the endothelial barrier functions to the passage of plasma molecules and inflammatory cells.Another area of research focuses on the role of Nogo-B, belonging to the Reticulon-4 family of proteins expressed in the ER, in vascular function regulation and in cardiac hypertrophy development.

Active Projects

  • To study the role of eNOS in vascular permeability and inflammatory cell recruitment to the site of inflammation.
  • To investigate the role of Nogo-B in vascular function and cardiac hypertrophy.


PI: Dr. Annarita Di Lorenzo, Ph.D.
National Institutes of Health (NIH)

PI: Annarita Di Lorenzo, Ph.D.
Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research

PI: Annarita Di Lorenzo, Ph.D.
American Heart Association (AHA)

Lab Team

Vascular and Sphingolipid Biology Lab Team

Additional Key Academic Personnel

Onorina Laura Manzo
Post Doc

Contact Information

Pathology and Laboratory Medicine
Weill Cornell Medical College

Annarita DiLorenzo, Ph.D.
Associate Professor of Pathology and Laboratory Medicine

1300 York Avenue
New York, NY 10065

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700