Proteolytic Oncogenesis

Principal Investigator: 
Pengbo Zhou, Ph.D.

Selective degradation of specific cellular proteins by the ubiquitin-proteasome pathway (UPP) is essential for a variety of vital cellular functions. We are interested in aspects of the UPP pertaining to physiological and pathological conditions, including the onset and maintenance of tumor growth as well as drug susceptibility.

Active Projects

  • The role of CRL4 ubiquitin ligase in tumorigenesis and chemotherapy resistance.
  • Ubiquitination and degradation of proteins involved in normal and malignant hematopoiesis.
  • CRL4 function in embryonic development, reproduction, and neurological disease


PI: Pengbo Zhou, Ph.D.
National Institutes of Health (NIH) Research Grant

PI: Pengbo Zhou, Ph.D.
Cullinogen, Inc Sponsored Research Agreement

PI: Pengbo Zhou, Ph.D.
The Daedalus Fund For Innovation Research Grant

PI: Pengbo Zhou, Ph.D.

PI: Pengbo Zhou, Ph.D.
National Institutes of Health (NIH)

PI: Pengbo Zhou, Ph.D.
National Institutes of Health (NIH)

PI: Pengbo Zhou, Ph.D.
Clinical & Translational Science Center (CTSC)

PI: Pengbo Zhou, PhD
Co-PI: Xiaojing Ma
National Institutes of Health (R01 grant)

PI: Massimo Loda, MD
PI Pilot Award: Pengbo Zhou, PhD
National Institutes of Health/WCM (SPORE DRP Pilot grant)

PI: Pengbo Zhou, PhD
WCM Clinical and Translational Science Center 

Lab Team

Proteolytic Oncogenesis Lab Team

Additional Key Academic Personnel

Wei Wei Gao
Post Doc
Bingfang Liu
Sr. Research Associate
Chandrani Mukhopadhyay
Research Associate
Sarah See
Research Associate
Fan Yan
Research Associate
Chenyi Yang
Research Associate

Contact Information

Pengbo Zhou, Ph.D.
Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College

1300 York Avenue
New York, NY 10065

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700