Pathology & Laboratory Medicine

Proteolytic Oncogenesis

Principal Investigator: 
Pengbo Zhou, Ph.D.

Selective degradation of specific cellular proteins by the ubiquitin-proteasome pathway (UPP) is essential for a variety of vital cellular functions. We are interested in aspects of the UPP pertaining to physiological and pathological conditions, including the onset and maintenance of tumor growth as well as drug susceptibility.

Active Projects

  • The role of CRL4 ubiquitin ligase in tumorigenesis and chemotherapy resistance.
  • Ubiquitination and degradation of proteins involved in normal and malignant hematopoiesis.
  • CRL4 function in embryonic development, reproduction, and neurological disease

Grants

Harnessing the CRL4 ubiquitin ligase for antagonizing colorectal carcinogenesis

PI: Pengbo Zhou, Ph.D.
National Institutes of Health (NIH) Research Grant

Validation of CUL4B mAbs

PI: Pengbo Zhou, Ph.D.
Cullinogen, Inc Sponsored Research Agreement

Ubiquitin Ligase Inhibitors as Protective Agents Against Cancer

PI: Pengbo Zhou, Ph.D.
The Daedalus Fund For Innovation Research Grant

Identification of small molecule inhibitors of the CRL4 ubiquitin ligase

PI: Pengbo Zhou, Ph.D.
Sanofi-Aventis

Regulation of Nucleotide Excision Repair by Proteolysis

PI: Pengbo Zhou, Ph.D.
National Institutes of Health (NIH)

Tumorigenic Role of the CUL4A Ubiquitin Ligas

PI: Pengbo Zhou, Ph.D.
National Institutes of Health (NIH)

Small. Molecule inhibitors of G3BP1 reinvigorate SPOP tumor suppressor

PI: Pengbo Zhou, Ph.D.
Clinical & Translational Science Center (CTSC)

UBR5's mechanisms of action in tumorigenesis and immunoregulation

PI: Pengbo Zhou, PhD
Co-PI: Xiaojing Ma
National Institutes of Health (R01 grant)

Weill Cornell Medicine (WCM) SPORE in Prostate Cancer

PI: Massimo Loda, MD
PI Pilot Award: Pengbo Zhou, PhD
National Institutes of Health/WCM (SPORE DRP Pilot grant)

WCM Clinical and Translational Science Center (CTSC)

PI: Pengbo Zhou, PhD
WCM Clinical and Translational Science Center 

Publications

Faculty

Pengbo Zhou, Ph.D.
Pengbo ZhouPh.D.
  • Principal Investigator
  • Professor of Pathology and Laboratory Medicine
Research Profile

Lab Team

Proteolytic Oncogenesis Lab Team

Additional Key Academic Personnel

Wei Wei Gao
Post Doc
weg2006@med.cornell.edu
Chandrani Mukhopadhyay
Research Associate
chm2067@med.cornell.edu
Sarah See
Research Associate
sas7064@med.cornell.edu
Fan Yan
Research Associate
fay2008@med.cornell.edu
Chenyi Yang
Research Associate
chy2008@med.cornell.edu

Contact Information

Pengbo Zhou, Ph.D.
Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College

1300 York Avenue
C-312
New York, NY 10065
Phone: 
212-746-6425
Fax: 
212-746-4483
Email: 
pez2001@med.cornell.edu
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Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
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