Title | A user's guide to the encyclopedia of DNA elements (ENCODE). |
Publication Type | Journal Article |
Year of Publication | 2011 |
Corporate Authors | ENCODE Project Consortium |
Journal | PLoS Biol |
Volume | 9 |
Issue | 4 |
Pagination | e1001046 |
Date Published | 2011 Apr |
ISSN | 1545-7885 |
Keywords | Base Sequence, Chromatin, Conserved Sequence, Databases, Nucleic Acid, DNA Methylation, DNA-Binding Proteins, Gene Components, Gene Expression Regulation, Genome, Human, Humans, Internet, Models, Genetic, Quality Control, RNA, Messenger, RNA-Binding Proteins |
Abstract | The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome. |
DOI | 10.1371/journal.pbio.1001046 |
Alternate Journal | PLoS Biol |
PubMed ID | 21526222 |
PubMed Central ID | PMC3079585 |
Grant List | R01 HG004037 / HG / NHGRI NIH HHS / United States RC2 HG005573 / HG / NHGRI NIH HHS / United States R01 HG003143 / HG / NHGRI NIH HHS / United States R01 DK054369 / DK / NIDDK NIH HHS / United States 095908 / / Wellcome Trust / United Kingdom R01 DK065806 / DK / NIDDK NIH HHS / United States |
Related Faculty:
Andrea Sboner, Ph.D.