|Title||A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Tong J, Luo J, Saldinger PF, Rodgers WH|
|Journal||Case Rep Hematol|
Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature.
|Alternate Journal||Case Rep Hematol|
|PubMed Central ID||PMC7960056|
William Rodgers, M.D., Ph.D.