A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?

TitleA Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?
Publication TypeJournal Article
Year of Publication2021
AuthorsTong J, Luo J, Saldinger PF, Rodgers WH
JournalCase Rep Hematol
Volume2021
Pagination8856649
Date Published2021
ISSN2090-6560
Abstract

Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature.

DOI10.1155/2021/8856649
Alternate JournalCase Rep Hematol
PubMed ID33747577
PubMed Central IDPMC7960056
Related Faculty: 
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