Primary cutaneous follicle center lymphoma associated with an extracutaneous dissemination: a cytogenetic finding of potential prognostic value.

TitlePrimary cutaneous follicle center lymphoma associated with an extracutaneous dissemination: a cytogenetic finding of potential prognostic value.
Publication TypeJournal Article
Year of Publication2015
AuthorsSubramaniyam S, Magro CM, Gogineni S, Tam W, Mathew S
JournalAm J Clin Pathol
Volume144
Issue5
Pagination805-10
Date Published2015 Nov
ISSN1943-7722
KeywordsCytogenetics, DNA-Binding Proteins, Female, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Light Chains, Lymphoma, Follicular, Middle Aged, Prognosis, Proto-Oncogene Proteins c-bcl-6, Skin, Skin Neoplasms, Translocation, Genetic
Abstract

OBJECTIVES: Cytogenetic studies on cutaneous lymphomas are rare, and very little is known about their prognostic value. We present a rare case of primary cutaneous follicle center lymphoma (PCFCL) with a complex translocation presenting with cutaneous and extracutaneous dissemination in the lymph node.

METHODS: Morphologic, immunohistochemical, conventional cytogenetic, and fluorescence in situ hybridization (FISH) studies were performed on this patient.

RESULTS: A combination of cytogenetic and FISH analysis identified a complex novel four-way t(2;14;9;3) (p11.2;q32;p13;q27) translocation involving rearrangements of BCL6, immunoglobulin light and heavy chain genes, and an unknown gene on 9p.

CONCLUSIONS: Our report elaborates the morphologic and immunohistochemical features in combination with cytogenetic and molecular cytogenetic analysis of PCFCL, which provide additional insight into the clinical and biologic behavior of this lesion.

DOI10.1309/AJCPV3F9BEFCTAOQ
Alternate JournalAm J Clin Pathol
PubMed ID26486746
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Cynthia M. Magro, M.D.

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