Title | Pathogenesis of Kaposi's sarcoma. |
Publication Type | Journal Article |
Year of Publication | 2003 |
Authors | Bubman D, Cesarman E |
Journal | Hematol Oncol Clin North Am |
Volume | 17 |
Issue | 3 |
Pagination | 717-45 |
Date Published | 2003 Jun |
ISSN | 0889-8588 |
Keywords | Animals, Biological Factors, Cell Culture Techniques, Disease Models, Animal, Genes, Viral, Herpesvirus 8, Human, HIV-1, Humans, Sarcoma, Kaposi |
Abstract | Kaposi's sarcoma (KS) is a disease characterized by proliferative vascular lesions, which almost invariably contain the KS-associated herpesvirus (KSHV), also called human herpesvirus 8. KSHV is a lymphotrophic and angiotrophic herpesvirus, whose genome encodes several proteins involved in proliferation, antiapoptotic functions, and inflammation. Most KS spindle cells express latent KSHV genes, but a few express lytic genes, which might be involved in angiogenic and paracrine mechanisms that contribute to KS pathogenesis. A number of tissue culture and mouse models have been established, but a comprehensive system that accurately portrays KS pathogenesis still does not exist. |
DOI | 10.1016/s0889-8588(03)00044-3 |
Alternate Journal | Hematol Oncol Clin North Am |
PubMed ID | 12852653 |
Related Faculty:
Ethel Cesarman, M.D., Ph.D.