| Title | Induction by interleukin-1beta peptide of prostaglandin E2 formation via enhanced prostaglandin H synthase-2 expression in 3T6 fibroblasts. |
| Publication Type | Journal Article |
| Year of Publication | 1998 |
| Authors | Sanchez T, Moreno JJ |
| Journal | Biochem Pharmacol |
| Volume | 56 |
| Issue | 6 |
| Pagination | 759-61 |
| Date Published | 1998 Sep 15 |
| ISSN | 0006-2952 |
| Keywords | Animals, Arachidonic Acid, Cells, Cultured, Dinoprostone, Enzyme Induction, Fibroblasts, Interleukin-1, Mice, Peptide Fragments, Prostaglandin-Endoperoxide Synthases |
| Abstract | Several synthetic interleukin-1 (IL-1) peptides were tested in vivo for pyrogenic activity and in vivo for their ability to stimulate prostaglandin production. Only the IL-1beta fragment (208-240) enhanced body temperature, although both IL-1beta (208-240) and IL-1alpha (223-250) stimulated prostaglandin E2 (PGE2) production in vitro. We report here that the IL-1beta fragment (208-240) did not have the capacity to induce arachidonic acid (AA) mobilization by 3T6 fibroblasts. However, this peptide was able to increase the expression of the inducible prostaglandin H synthase isoform (PGHS-2; EC 1.14.99.1.), which is related to its ability to stimulate prostaglandin E2 synthesis. |
| DOI | 10.1016/s0006-2952(98)00056-2 |
| Alternate Journal | Biochem Pharmacol |
| PubMed ID | 9751081 |
Related Faculty:
Teresa Sanchez, Ph.D.