| Title | Genomic lesions associated with a different clinical outcome in diffuse large B-Cell lymphoma treated with R-CHOP-21. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Scandurra M, Mian M, Greiner TC, Rancoita PMV, De Campos CP, Chan WC, Vose JM, Chigrinova E, Inghirami G, Chiappella A, Baldini L, Ponzoni M, Ferreri AJM, Franceschetti S, Gaidano G, Montes-Moreno S, Piris MA, Facchetti F, Tucci A, Nomdedeu JFr, Lazure T, Lambotte O, Uccella S, Pinotti G, Pruneri G, Martinelli G, Young KH, Tibiletti MGrazia, Rinaldi A, Zucca E, Kwee I, Bertoni F |
| Journal | Br J Haematol |
| Volume | 151 |
| Issue | 3 |
| Pagination | 221-31 |
| Date Published | 2010 Nov |
| ISSN | 1365-2141 |
| Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Murine-Derived, Antineoplastic Combined Chemotherapy Protocols, Chromosome Aberrations, Chromosome Deletion, Chromosomes, Human, Pair 8, Comparative Genomic Hybridization, Cyclophosphamide, Doxorubicin, Epidemiologic Methods, Female, Humans, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Polymorphism, Single Nucleotide, Prednisone, Rituximab, Signal Transduction, Treatment Outcome, Vincristine, Young Adult |
| Abstract | Despite recent therapeutic improvements, the clinical course of diffuse large B-cell lymphoma (DLBCL) still differs considerably among patients. We conducted this retrospective multi-centre study to evaluate the impact of genomic aberrations detected using a high-density genome wide-single nucleotide polymorphism-based array on clinical outcome in a population of DLBCL patients treated with R-CHOP-21 (rituximab, cyclophosphamide, doxorubicine, vincristine and prednisone repeated every 21 d). 166 DNA samples were analysed using the GeneChip Human Mapping 250K NspI. Genomic anomalies were analysed regarding their impact on the clinical course of 124 patients treated with R-CHOP-21. Unsupervised clustering was performed to identify genetically related subgroups of patients with different clinical outcomes. Twenty recurrent genetic lesions showed an impact on the clinical course. Loss of genomic material at 8p23.1 showed the strongest statistical significance and was associated with additional aberrations, such as 17p- and 15q-. Unsupervised clustering identified five DLBCL clusters with distinct genetic profiles, clinical characteristics and outcomes. Genetic features and clusters, associated with a different outcome in patients treated with R-CHOP, have been identified by arrayCGH. |
| DOI | 10.1111/j.1365-2141.2010.08326.x |
| Alternate Journal | Br J Haematol |
| PubMed ID | 20813005 |
| Grant List | UO1 CA 114778 / CA / NCI NIH HHS / United States |
Related Faculty:
Giorgio Inghirami, M.D.