| Title | FoxO family members in cancer. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Zhang Y, Gan B, Liu D, Paik J-H |
| Journal | Cancer Biol Ther |
| Volume | 12 |
| Issue | 4 |
| Pagination | 253-9 |
| Date Published | 2011 Aug 15 |
| ISSN | 1555-8576 |
| Keywords | Apoptosis, Autophagy, Cell Cycle, Cell Cycle Proteins, Drug Resistance, Neoplasm, Forkhead Box Protein O1, Forkhead Box Protein O3, Forkhead Transcription Factors, Humans, Models, Biological, Neoplasms, Signal Transduction, Transcription Factors |
| Abstract | The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological processes including cellular energy storage, growth, and survival, among others. As an important effector of this pathway, FoxO is involved in versatile activities that protect organisms from stress and aging. Recent studies on mammalian FoxO have established a direct role for this transcription factor family in cellular proliferation, oxidative stress response, and tumorigenesis. The review will focus on the recent developments pertaining to the function of FoxO as well as discuss the various contexts in which FoxO exerts distinct biological activity such as drug resistance and autophagy in cancer pathogenesis and therapy. |
| DOI | 10.4161/cbt.12.4.15954 |
| Alternate Journal | Cancer Biol Ther |
| PubMed ID | 21613825 |
Related Faculty:
Ji-Hye Paik, Ph.D.