| Title | The EZH2 polycomb transcriptional repressor--a marker or mover of metastatic prostate cancer? |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Sellers WR, Loda M |
| Journal | Cancer Cell |
| Volume | 2 |
| Issue | 5 |
| Pagination | 349-50 |
| Date Published | 2002 Nov |
| ISSN | 1535-6108 |
| Keywords | Biomarkers, Tumor, DNA-Binding Proteins, Enhancer of Zeste Homolog 2 Protein, Gene Expression Profiling, Gene Expression Regulation, Humans, Male, Oligonucleotide Array Sequence Analysis, Polycomb Repressive Complex 2, Prostatic Neoplasms, Proteins, Repressor Proteins, RNA, Messenger, Transcription Factors, Transcription, Genetic, Treatment Outcome |
| Abstract | The recent finding of overexpression of the polycomb group transcriptional repressor EZH2 in prostate cancer raises the possibility that transcriptional regulation at the chromatin level may play a role in the development of the metastatic phenotype and suggests new avenues of exploration with respect to patient stratification and therapeutics. |
| DOI | 10.1016/s1535-6108(02)00187-3 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 12450788 |
Related Faculty:
Massimo Loda, M.D.