| Title | Endothelial cell growth factor and ionophore A23187 stimulation of production of inositol phosphates in porcine aorta endothelial cells. |
| Publication Type | Journal Article |
| Year of Publication | 1988 |
| Authors | Moscat J, Moreno F, Herrero C, Lopez C, Garcia-Barreno P |
| Journal | Proc Natl Acad Sci U S A |
| Volume | 85 |
| Issue | 3 |
| Pagination | 659-63 |
| Date Published | 1988 Feb |
| ISSN | 0027-8424 |
| Keywords | Animals, Aorta, Calcimycin, Calcium, Cells, Cultured, Endothelium, Vascular, Fibroblast Growth Factors, Inositol Phosphates, Stimulation, Chemical, Sugar Phosphates, Swine, Type C Phospholipases |
| Abstract | The existence of a bovine brain-derived endothelial cell growth factor has recently been reported, but its mode of action is unknown. We show that the endothelial cell growth factor is a potent stimulant of inositol monophosphate release in porcine aorta endothelial cells. Although the activation of phospholipase C by this factor does not appear to be dependent on Ca2+, the Ca2+ ionophore A23187 stimulates release of inositol phosphates. It is suggested that the inositol 1,4,5-trisphosphate 3-kinase/5-phosphomonoesterase pathway could account for the ionophore-induced changes in inositol 1,3,4-triphosphate. |
| DOI | 10.1073/pnas.85.3.659 |
| Alternate Journal | Proc Natl Acad Sci U S A |
| PubMed ID | 3124109 |
| PubMed Central ID | PMC279614 |
Related Faculty:
Jorge Moscat, Ph.D.