|Title||Endothelial cell growth factor and ionophore A23187 stimulation of production of inositol phosphates in porcine aorta endothelial cells.|
|Publication Type||Journal Article|
|Year of Publication||1988|
|Authors||Moscat J, Moreno F, Herrero C, Lopez C, Garcia-Barreno P|
|Journal||Proc Natl Acad Sci U S A|
|Date Published||1988 Feb|
|Keywords||Animals, Aorta, Calcimycin, Calcium, Cells, Cultured, Endothelium, Vascular, Fibroblast Growth Factors, Inositol Phosphates, Stimulation, Chemical, Sugar Phosphates, Swine, Type C Phospholipases|
The existence of a bovine brain-derived endothelial cell growth factor has recently been reported, but its mode of action is unknown. We show that the endothelial cell growth factor is a potent stimulant of inositol monophosphate release in porcine aorta endothelial cells. Although the activation of phospholipase C by this factor does not appear to be dependent on Ca2+, the Ca2+ ionophore A23187 stimulates release of inositol phosphates. It is suggested that the inositol 1,4,5-trisphosphate 3-kinase/5-phosphomonoesterase pathway could account for the ionophore-induced changes in inositol 1,3,4-triphosphate.
|Alternate Journal||Proc Natl Acad Sci U S A|
|PubMed Central ID||PMC279614|
Jorge Moscat, Ph.D.