| Title | Cytomorphologic characteristics and differential diagnoses of lymphoepithelial carcinoma of the parotid. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Hipp JA, Jing X, Zarka MA, Schmitt AC, Siddiqui MT, Wakely P, Bishop J, Ali SZ |
| Journal | J Am Soc Cytopathol |
| Volume | 5 |
| Issue | 2 |
| Pagination | 93-99 |
| Date Published | 2016 Mar - Apr |
| ISSN | 2213-2945 |
| Abstract | INTRODUCTION: Lymphoepithelial carcinoma of the salivary gland is an extremely rare neoplasm and is challenging to diagnose by fine needle aspiration (FNA). There are rare reports on the cytopathologic features of lymphoepithelial carcinoma, which may be mistaken for other high-grade salivary gland neoplasm or a metastasis to the salivary gland. MATERIALS AND METHODS: A retrospective review was undertaken of 7 cases of lymphoepithelial carcinoma of the parotid diagnosed on FNA with histologic confirmation from 4 major medical centers. RESULTS: Cytomorphologic features of lymphoepithelial carcinoma include smears with moderate cellularity displaying a rich nonneoplastic population of lymphoplasmacytic cells admixed with tissue fragments of high grade, malignant undifferentiated epithelial cells with high nuclear to cytoplasm ratio, hyperchromasia, prominent nucleoli, and scant to abundant, indistinct cytoplasm. DISCUSSION: Diagnostic pitfalls of lymphoepithelial carcinoma include metastatic squamous cell carcinoma, metastatic nasopharyngeal carcinoma, and other high grade primary salivary gland neoplasms. Recognizing this lesion may help guide clinicians to perform additional imaging studies to exclude a primary from other sites. |
| DOI | 10.1016/j.jasc.2015.09.216 |
| Alternate Journal | J Am Soc Cytopathol |
| PubMed ID | 31042496 |
Related Faculty:
Momin Siddiqui, M.D.