Title | Cytological diagnosis of papillary thyroid carcinoma with tall cells on ThinPrep liquid-based cytology. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Baum JE, Soong L, Scognamiglio T, Margolskee EM, Hoda RS, Rao R |
Journal | Diagn Cytopathol |
Volume | 47 |
Issue | 6 |
Pagination | 541-546 |
Date Published | 2019 Jun |
ISSN | 1097-0339 |
Keywords | Cell Nucleus, Cytodiagnosis, Female, Humans, Liquid Biopsy, Male, Middle Aged, Thyroid Cancer, Papillary, Thyroid Gland, Thyroid Neoplasms |
Abstract | BACKGROUND: The tall cell variant of papillary thyroid carcinoma (PTC-TC) has been associated with aggressive features including extrathyroidal extension, higher rate of lymph node and distant metastases, and higher recurrence rate. We aimed to evaluate the cytomorphologic features of PTC-TC on ThinPrep (TP) along with its diagnostic efficacy to detect PTC-TC. METHODS: Preoperative cytology samples from 30 cases of histologically-proven PTC-TC and 30 classical PTC controls were selected for this study. TP preparations were evaluated for varying architectural and cytomorphologic features. RESULTS: Tall cells were present in the majority of PTC-TC cases and were located at the periphery of cell clusters and as single cells. Cytoplasmic cuff along the periphery of cell clusters and soap-bubble pseudoinclusions were very specific features of PTC-TC, when present. PTC-TC cases were more likely to show abundant oncocytic cytoplasm and distinct cell borders. Cytoplasmic tails were more likely to be present and more numerous in PTC-TC. The presence of nuclear grooves, papillary architecture, and giant cells were not reliable distinguishing features of PTC-TC vs controls. CONCLUSION: Our results indicate that tall cell cytomorphologic and architectural features in PTC are identifiable on TP. |
DOI | 10.1002/dc.24146 |
Alternate Journal | Diagn Cytopathol |
PubMed ID | 30648353 |
Related Faculty:
Theresa Scognamiglio, M.D.