Title | Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: a case report. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Alsharif M, Aslan DL, Jessurun J, H Gulbahce E, Pambuccian SE |
Journal | Diagn Cytopathol |
Volume | 36 |
Issue | 10 |
Pagination | 734-8 |
Date Published | 2008 Oct |
ISSN | 1097-0339 |
Keywords | Adult, Alkaline Phosphatase, Biopsy, Humans, Isoenzymes, Male, Octamer Transcription Factor-3, Prostate, Prostatic Neoplasms, Proto-Oncogene Proteins c-kit, Seminoma, Testicular Neoplasms, Urinary Bladder Neoplasms, Urine |
Abstract | A 42-year-old man presented with severe abdominal pain, constipation, and hematuria. The patient had a history of seminoma treated by chemotherapy followed by bilateral orchiectomy and retroperitoneal lymph node dissection 16 years earlier. A computed tomography (CT) scan showed a 8.0 x 6.0 x 5.0 cm mass in the retrovesical space, encompassing the left side of his proximal bladder, the prostate, and the rectum. A urine cytologic specimen showed loosely cohesive cell clusters composed of highly atypical large cells and occasional large, single cells with macronucleoli present in a background of mainly lymphocytes and histiocytes was diagnosed as recurrent seminoma. Prostate biopsies showed extensively necrotic seminoma with accompanying granulomatous reaction. The tumor cells were immunoreactive for c-kit (CD117), placental-like alkaline phosphatase (PLAP), D2-40, and OCT4. To our knowledge, this is the second report on urine cytology of metastatic seminoma. |
DOI | 10.1002/dc.20881 |
Alternate Journal | Diagn Cytopathol |
PubMed ID | 18773441 |
Related Faculty:
Jose Jessurun, M.D.