| Title | Colonic Mucosa With Polypoid Hyperplasia. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Hissong E, Fernandes H, Jessurun J |
| Journal | Am J Clin Pathol |
| Volume | 152 |
| Issue | 4 |
| Pagination | 423-430 |
| Date Published | 2019 09 09 |
| ISSN | 1943-7722 |
| Keywords | Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Colon, Colonic Polyps, Colonoscopy, Female, High-Throughput Nucleotide Sequencing, Humans, Hyperplasia, Intestinal Mucosa, Male, Middle Aged, Proto-Oncogene Proteins p21(ras) |
| Abstract | OBJECTIVES: Define the morphologic and molecular features of colonic polyps with subtle histologic features. METHODS: Two hundred specimens were obtained of surveillance colonoscopies. Endoscopic findings were reviewed. Histologic features of the polyps were compared with the flat mucosa. Next-generation sequencing was performed on 30 study polyps and 20 control samples. RESULTS: Polyps with subtle changes comprised 12% of all polyps. All polyps were sessile and small (<0.5 cm) and were located predominantly in the distal colon (60%). Synchronous hyperplastic, sessile serrated, and dysplastic polyps were found in 30%, 7%, and 51% of patients, respectively. A total of 169 (84.5%) polyps showed wide, nonserrated crypts, increased intraluminal mucus, and patent openings. KRAS alterations were present in 30% of polyps. CONCLUSIONS: Most polyps with subtle histologic features have recognizable morphologic changes. About one-third harbored KRAS alterations. These polyps should not be regarded as variants of hyperplastic polyps. |
| DOI | 10.1093/ajcp/aqz053 |
| Alternate Journal | Am J Clin Pathol |
| PubMed ID | 31152544 |
Related Faculty:
Jose Jessurun, M.D.