Title | Is c-Met oncoprotein expression an adverse prognosticator in extrahepatic bile duct cancer treated with curative resection followed by adjuvant chemoradiotherapy? |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Park HJ, Kim K, Paik JH, Chie EK, Kim S, Jang J-Y, Kim SW, Han S-W, Oh D-Y, Im S-A, Kim T-Y, Bang Y-J, Ha SW |
Journal | Clin Transl Oncol |
Volume | 18 |
Issue | 6 |
Pagination | 625-31 |
Date Published | 2016 Jun |
ISSN | 1699-3055 |
Keywords | Adult, Aged, Bile Duct Neoplasms, Bile Ducts, Extrahepatic, Biomarkers, Tumor, Chemoradiotherapy, Adjuvant, Digestive System Surgical Procedures, Disease-Free Survival, Female, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Proto-Oncogene Proteins c-met, Tissue Array Analysis, Young Adult |
Abstract | PURPOSE: To analyze the expression of c-Met, and to investigate correlations between the expression of c-Met, clinicopathologic variables, and survival in patients undergoing curative surgery followed by adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Ninety EHBD cancer patients who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled. Expression of c-Met was assessed with immunohistochemical staining on tissue microarray. The correlation between clinicopathologic variables and survival outcomes was evaluated using Kaplan-Meier method and Cox proportional hazard model. RESULTS: On univariate analysis, 66 patients (76.7 %) showed c-Met expression. c-Met expression had a significant impact on 5-year overall survival (OS) (43.0 % in c-Met(+) vs. 25.0 % in c-Met(-), p = 0.0324), but not on loco-regional relapse-free survival or distant metastasis-free survival (DMFS). However, on multivariate analysis incorporating tumor location and nodal involvement, survival difference was not maintained (p = 0.2940). Tumor location was the only independent prognostic factor predicting OS (p = 0.0089). Hilar location tumors, nodal involvement, and poorly differentiated tumors were all identified as independent prognostic factors predicting inferior DMFS (p = 0.0030, 0.0013, and 0.0037, respectively). CONCLUSIONS: This study showed that c-Met expression was not associated with survival outcomes in EHBD cancer patients undergoing curative resection followed by adjuvant chemoradiotherapy. Further studies are needed to fully elucidate the prognostic value of c-Met expression in these patients. |
DOI | 10.1007/s12094-015-1409-5 |
Alternate Journal | Clin Transl Oncol |
PubMed ID | 26459257 |
Related Faculty:
Ji-Hye Paik, Ph.D.