Title | B-Cell and Classical Hodgkin Lymphomas Associated With Immunodeficiency: 2015 SH/EAHP Workshop Report-Part 2. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | de Jong D, Roemer MGM, Chan JKC, Goodlad J, Gratzinger D, Chadburn A, Jaffe ES, Said J, Natkunam Y |
Journal | Am J Clin Pathol |
Volume | 147 |
Issue | 2 |
Pagination | 153-170 |
Date Published | 2017 Feb 01 |
ISSN | 1943-7722 |
Keywords | Education, Epstein-Barr Virus Infections, Female, Hodgkin Disease, Humans, Immunologic Deficiency Syndromes, Lymphoma, B-Cell, Male |
Abstract | Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology submitted small and large B-cell lymphomas (BCLs), including classical Hodgkin lymphoma (CHL), in the context of immunodeficiency. Methods: Clinicopathologic and molecular features were studied to explore unifying concepts in malignant B-cell proliferations across immunodeficiency settings. Results: Cases submitted to the workshop spanned small BCLs presenting as nodal or extranodal marginal zone lymphoma and lymphoplasmacytic lymphoma, Epstein-Barr virus (EBV) positive in 75% of cases. Submitted large BCLs formed a spectrum from diffuse large B-cell lymphoma (DLBCL) to CHL across immunodeficiency settings. Additional studies demonstrated overexpression of PD-L1 and molecular 9p24 alterations in the large BCL spectrum and across different immunodeficiency settings. Conclusions: Small BCLs occur in all immunodeficiency settings, and EBV positivity is essential for their recognition as immunodeficiency related. Large BCLs include a spectrum from DLBCL to CHL across all immunodeficiency settings; immunohistochemical and molecular features are suggestive of shared pathogenetic mechanisms involving PD-L1 immune checkpoints. |
DOI | 10.1093/ajcp/aqw216 |
Alternate Journal | Am J Clin Pathol |
PubMed ID | 28395108 |
PubMed Central ID | PMC6248547 |
Related Faculty:
Amy Chadburn, M.D.