| Title | Anchoring Chromatin Loops to Cancer. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Fowler F, Tyler JK |
| Journal | Dev Cell |
| Volume | 42 |
| Issue | 3 |
| Pagination | 209-211 |
| Date Published | 2017 08 07 |
| ISSN | 1878-1551 |
| Keywords | Chromatin, DNA Breaks, Double-Stranded, DNA Replication, Humans, Neoplasms, Translocation, Genetic |
| Abstract | Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors generates DNA double-strand breaks that drive multiple oncogenic translocations in a transcription-independent manner. |
| DOI | 10.1016/j.devcel.2017.07.013 |
| Alternate Journal | Dev Cell |
| PubMed ID | 28787588 |
| PubMed Central ID | PMC5859922 |
| Grant List | R01 CA095641 / CA / NCI NIH HHS / United States R01 GM064475 / GM / NIGMS NIH HHS / United States |
Related Faculty:
Jessica K. Tyler, Ph.D.