Title | Control of regulatory T cell lineage commitment and maintenance. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Josefowicz SZ, Rudensky A |
Journal | Immunity |
Volume | 30 |
Issue | 5 |
Pagination | 616-25 |
Date Published | 2009 May |
ISSN | 1097-4180 |
Keywords | Animals, Cell Differentiation, Cell Lineage, Cytokines, Forkhead Transcription Factors, Humans, Protein Kinases, Receptors, Antigen, T-Cell, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory, Thymus Gland |
Abstract | Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against self and foreign antigens and commensal microorganisms. Sustained expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is required for their differentiation and suppressor function. In addition, Foxp3 expression prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg cell survival and expansion on growth factors, foremost interleukin-2, provided by activated effector T cells. In this review we discuss Treg cell differentiation and maintenance with a particular emphasis on molecular regulation of Foxp3 expression, arguably a key to mechanistic understanding of biology of regulatory T cells. |
DOI | 10.1016/j.immuni.2009.04.009 |
Alternate Journal | Immunity |
PubMed ID | 19464984 |
PubMed Central ID | PMC4410181 |
Grant List | R01 AI061816 / AI / NIAID NIH HHS / United States AI061816 / AI / NIAID NIH HHS / United States |
Related Faculty:
Steven Josefowicz, Ph.D.