| Title | Well-differentiated hepatocellular carcinoma associated with long-term survival. Report of two cases. |
| Publication Type | Journal Article |
| Year of Publication | 1991 |
| Authors | Loda M, Mendoza AE, O'Hara C, Crawford JM, Federman M, Goodman H |
| Journal | Virchows Arch A Pathol Anat Histopathol |
| Volume | 418 |
| Issue | 6 |
| Pagination | 551-6 |
| Date Published | 1991 |
| ISSN | 0174-7398 |
| Keywords | Adult, alpha 1-Antichymotrypsin, alpha 1-Antitrypsin, Bile Ducts, Carcinoembryonic Antigen, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Chorionic Gonadotropin, Chromogranins, Female, Hepatic Duct, Common, Humans, Immunohistochemistry, Keratins, Liver Neoplasms, Male, Membrane Glycoproteins, Microscopy, Electron, Middle Aged, Mucin-1, Phosphopyruvate Hydratase, Prognosis, Time Factors, Vimentin |
| Abstract | Two cases of well-differentiated hepatocellular carcinoma (HCC) with focal biliary differentiation are presented. The distinct histological features of these neoplasms and the unusually protracted clinical course of 8 and 10 years distinguish them from previously described pathological categories of primary hepatic tumors. Electron microscopic and immunohistochemical findings support a dual hepatic and bile duct differentiation of the tumor cells. If additional examples of this tumor are found to be associated with a similarly prolonged symptom-free survival, the distinction of this entity from traditional, rapidly fatal HCC becomes important. Less aggressive therapeutic options may be entertained. |
| DOI | 10.1007/BF01606507 |
| Alternate Journal | Virchows Arch A Pathol Anat Histopathol |
| PubMed ID | 1711733 |
Related Faculty:
Massimo Loda, M.D.