| Title | Integrated profiling of diffuse large B-cell lymphoma with 7q gain. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Chigrinova E, Mian M, Shen Y, Greiner TC, Chan WC, Vose JM, Inghirami G, Chiappella A, Baldini L, Ponzoni M, Ferreri AJM, Franceschetti S, Gaidano G, Tucci A, Facchetti F, Lazure T, Lambotte O, Montes-Moreno S, Piris MA, Zucca E, Kwee I, Bertoni F |
| Journal | Br J Haematol |
| Volume | 153 |
| Issue | 4 |
| Pagination | 499-503 |
| Date Published | 2011 May |
| ISSN | 1365-2141 |
| Keywords | Aged, Antibodies, Monoclonal, Murine-Derived, Antineoplastic Combined Chemotherapy Protocols, Chromosome Duplication, Chromosomes, Human, Pair 7, Cyclophosphamide, Doxorubicin, Female, Follow-Up Studies, Gene Expression Profiling, Humans, Lymphoma, Large B-Cell, Diffuse, Male, MicroRNAs, Middle Aged, Prednisone, Prognosis, Rituximab, RNA, Neoplasm, Survival Analysis, Treatment Outcome, Vincristine |
| Abstract | To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR. |
| DOI | 10.1111/j.1365-2141.2011.08628.x |
| Alternate Journal | Br J Haematol |
| PubMed ID | 21418177 |
| Grant List | U01 CA 114778 / CA / NCI NIH HHS / United States |
Related Faculty:
Giorgio Inghirami, M.D.