ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer.

TitleULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer.
Publication TypeJournal Article
Year of Publication2021
AuthorsDeng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng DH, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong K-K
JournalNat Cancer
Volume2
Issue5
Pagination503-514
Date Published2021 05
ISSN2662-1347
KeywordsAntigen Presentation, Autophagy-Related Protein-1 Homolog, Carcinoma, Non-Small-Cell Lung, Humans, Intracellular Signaling Peptides and Proteins, Lung Neoplasms
DOI10.1038/s43018-021-00208-6
Alternate JournalNat Cancer
PubMed ID34142094
PubMed Central IDPMC8205437
Grant ListT32 CA009161 / CA / NCI NIH HHS / United States
P30 CA016087 / CA / NCI NIH HHS / United States
P01 CA117969 / CA / NCI NIH HHS / United States
R01 CA166480 / CA / NCI NIH HHS / United States
R01 CA205150 / CA / NCI NIH HHS / United States
P50 CA058223 / CA / NCI NIH HHS / United States
R01 CA219670 / CA / NCI NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
U01 CA233084 / CA / NCI NIH HHS / United States
R01 CA076584 / CA / NCI NIH HHS / United States
R01 CA215498 / CA / NCI NIH HHS / United States
Related Faculty: 
Antonio Marzio, Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
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