The spleen: anatomy and anatomical function.

TitleThe spleen: anatomy and anatomical function.
Publication TypeJournal Article
Year of Publication2000
AuthorsChadburn A
JournalSemin Hematol
Issue1 Suppl 1
Date Published2000 Jan
KeywordsAnimals, Humans, Spleen

In this review, our knowledge concerning the structure and function of the spleen is summarized. The unique architecture of the spleen allows for interactions between the circulatory, reticuloendothelial, and immune systems. Based on these interactions in conjunction with its microanatomy, the spleen is able to maintain the integrity of the blood and respond to circulating antigens. However, this can be a double-edged sword in the case of patients suffering from autoimmune diseases such as immune thrombocytopenic purpura since the spleen can be the site of both antibody production and circulating cell destruction.

Alternate JournalSemin Hematol
PubMed ID10676919
Related Faculty: 
Amy Chadburn, M.D.

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