Regulators of chromatin state and transcription in CD4 T-cell polarization.

TitleRegulators of chromatin state and transcription in CD4 T-cell polarization.
Publication TypeJournal Article
Year of Publication2013
AuthorsJosefowicz SZ
Date Published2013 Jul
KeywordsCD4-Positive T-Lymphocytes, Cell Differentiation, Chromatin, Gene Expression Regulation, Humans, Lymphocyte Activation, Transcription Factors

Mature naive CD4 T-cells possess the potential for an array of highly specialized functions, from inflammatory to potently suppressive. This potential is encoded in regulatory DNA elements and is fulfilled through modification of chromatin and selective activation by the collaborative function of diverse transcription factors in response to environmental cues. The mechanisms and strategies employed by transcription factors for the programming of CD4 T-cell subsets will be discussed. In particular, the focus will be on co-operative activity of environmental response factors in the initial activation of regulatory DNA elements and chromatin alteration, and the subsequent role of 'master regulator' transcription factors in defining the fidelity and environmental responsiveness of different CD4 T-cell subsets.

Alternate JournalImmunology
PubMed ID23590627
PubMed Central IDPMC3701176
Grant ListGM100616 / GM / NIGMS NIH HHS / United States
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