| Title | REGgamma: a shortcut to destruction. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Zhou P |
| Journal | Cell |
| Volume | 124 |
| Issue | 2 |
| Pagination | 256-7 |
| Date Published | 2006 Jan 27 |
| ISSN | 0092-8674 |
| Keywords | Acetyltransferases, Autoantigens, Histone Acetyltransferases, Nuclear Receptor Coactivator 3, Oncogene Proteins, Proteasome Endopeptidase Complex, Trans-Activators, Ubiquitin |
| Abstract | Destruction of intact cellular proteins is largely orchestrated by ATP-dependent ubiquitination and subsequent degradation by the 26S proteasome. The REG-20S proteasome, however, only degrades short peptides. In this issue of Cell, challenge this notion by revealing that the proteasomal activator REGgamma directs degradation of the steroid receptor coactivator SRC-3 by the 20S proteasome in an ATP- and ubiquitin-independent manner. |
| DOI | 10.1016/j.cell.2006.01.003 |
| Alternate Journal | Cell |
| PubMed ID | 16439199 |
Related Lab:
Related Faculty:
Pengbo Zhou, Ph.D.