|Title||Pseudosarcomatous changes in inflammatory pseudopolyps of the colon.|
|Publication Type||Journal Article|
|Year of Publication||1986|
|Authors||Jessurun J, Paplanus SH, Nagle RB, Hamilton SR, Yardley JH, Tripp M|
|Journal||Arch Pathol Lab Med|
|Date Published||1986 Sep|
|Keywords||Adolescent, Adult, Biopsy, Colitis, Ulcerative, Colonic Neoplasms, Colonic Polyps, Fibroma, Histocytochemistry, Humans, Male, Microscopy, Electron|
The occurrence of pseudomalignant changes in biopsy specimens from two patients with ulcerative colitis and pseudopolyposis is described. One lesion was characterized by the proliferation of large ganglion cell-like cells, similar to those observed in proliferative fasciitis. Ultrastructural and immunohistochemical findings supported a fibroblastic origin. Biopsy specimens of an inflammatory pseudopolyp from the second patient showed proliferation of oval to spindle cells that were initially interpreted as a possible neoplasm. The site of origin and reactive nature of this lesion became apparent on a subsequent polypectomy specimen. Attention is called to the occurrence of pseudosarcomatous changes in inflammatory pseudopolyps of the gastrointestinal tract that may lead to an erroneous diagnosis of malignancy.
|Alternate Journal||Arch Pathol Lab Med|
Jose Jessurun, M.D.