Title | Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Siscovick JR, Zapolanski T, Magro C, Carrington K, Prograis S, Nussbaum M, Gonzalez S, Ding W, Granstein RD |
Journal | Photodermatol Photoimmunol Photomed |
Volume | 24 |
Issue | 3 |
Pagination | 134-41 |
Date Published | 2008 Jun |
ISSN | 1600-0781 |
Keywords | Animals, Dermatitis, Allergic Contact, Ear, Immune Tolerance, Mice, Mice, Inbred C57BL, Oxazolone, Plant Extracts, Plant Leaves, Polypodium, Radiation Dosage, Skin, Ultraviolet Rays |
Abstract | BACKGROUND: An extract of the tropical fern Polypodium leucotomos (PL) administered orally to mice inhibits ultraviolet B (UVB) radiation-induced skin cancer formation. UVB-induced murine skin cancers occur, in part, because of UVB-induced immunosuppression. Thus, we examined whether PL inhibits UVB-suppression of the induction of contact hypersensitivity (CHS) locally or systemically. METHODS: C57BL/6 mice received standard drinking water or water-containing PL. In the local model, mice were shaved on the dorsum and exposed to 3500 J/m(2) of UVB radiation daily for 4 days. Control mice were not irradiated. After the last irradiation they were sensitized to oxazolone topically at the irradiated site. To examine the ability of PL to inhibit systemic UVB-induced immunosuppression, mice were given 10,000 J/m(2) of UVB radiation once and immunized at a non-exposed site 3 days later. Six days after immunization (in both models), mice were challenged on the ears with oxazolone and 24/48 h ear swelling assessed. RESULTS: PL in drinking water significantly reduced the inhibition of CHS observed with exposure to UVB radiation in both the local and systemic models. CONCLUSIONS: The ability of PL to inhibit UVB radiation-induced immune suppression may explain, in part, its ability to inhibit UVR-induced skin cancer induction in mice. |
DOI | 10.1111/j.1600-0781.2008.00352.x |
Alternate Journal | Photodermatol Photoimmunol Photomed |
PubMed ID | 18477132 |
Related Faculty:
Cynthia M. Magro, M.D.