Plasma Levels of Complement Factor I and C4b Peptides Are Associated with HIV Suppression.

TitlePlasma Levels of Complement Factor I and C4b Peptides Are Associated with HIV Suppression.
Publication TypeJournal Article
Year of Publication2017
AuthorsWu B, Ouyang Z, Lyon CJ, Zhang W, Clift T, Bone CR, Li B, Zhao Z, Kimata JT, Yu XG, Hu Y
JournalACS Infect Dis
Volume3
Issue12
Pagination880-885
Date Published2017 12 08
ISSN2373-8227
KeywordsAdult, Aged, Complement C4b, Complement Factor I, Female, Genotype, HIV Infections, HLA-B Antigens, Humans, Male, Middle Aged
Abstract

Individuals who exhibit long-term HIV suppression and CD4 T-cell preservation without antiretroviral therapy are of great interest for HIV research. There is currently no robust method for rapid identification of these "HIV controller" subjects; however, HLA-B*57 (human leukocyte antigen (major histocompatibility complex), class I, B*57) genotype exhibits modest sensitivity for this phenotype. Complement C3b and C4b can influence HIV infection and replication, but studies have not examined their possible link to HIV controller status. We analyzed HLA-B*57 genotype and complement levels in HIV-positive patients receiving suppressive antiretroviral therapy, untreated HIV controllers, and HIV-negative subjects to identify factors associated with HIV controller status. Our results revealed that the plasma levels of three C4b-derived peptides and complement factor I outperformed all other assayed biomarkers for HIV controller identification, although we could not analyze the predictive value of biomarker combinations with the current sample size. We believe this rapid screening approach may prove useful for improved identification of HIV controllers.

DOI10.1021/acsinfecdis.7b00042
Alternate JournalACS Infect Dis
PubMed ID28862830
PubMed Central IDPMC5727467
Grant ListR01 HL134539 / HL / NHLBI NIH HHS / United States
R01 AI122932 / AI / NIAID NIH HHS / United States
R56 AI098484 / AI / NIAID NIH HHS / United States
R21 AI126361 / AI / NIAID NIH HHS / United States
R01 AI113725 / AI / NIAID NIH HHS / United States
R01 HD090927 / HD / NICHD NIH HHS / United States
P30 AI036211 / AI / NIAID NIH HHS / United States
R56 HL126554 / HL / NHLBI NIH HHS / United States
Related Faculty: 
Zhen Zhao, Ph.D.

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