| Title | Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals. |
| Publication Type | Journal Article |
| Year of Publication | 1992 |
| Authors | Diaz-Meco MT, Dominguez I, Sanz L, Municio MM, Berra E, Cornet ME, A de Herreros G, Johansen T, Moscat J |
| Journal | Mol Cell Biol |
| Volume | 12 |
| Issue | 1 |
| Pagination | 302-8 |
| Date Published | 1992 Jan |
| ISSN | 0270-7306 |
| Keywords | Animals, Bacillus cereus, Cell Line, Enzyme Activation, Genes, myc, Hydrolysis, Insulin, Keratinocytes, Kinetics, Mice, Microinjections, Oocytes, Phosphatidylcholines, Progesterone, Protamine Kinase, Proto-Oncogene Proteins p21(ras), Transforming Growth Factor beta, Type C Phospholipases, Xenopus laevis |
| Abstract | Cell growth and tumor transformation can be restrained in certain cell systems by the action of transforming growth factor beta (TGF-beta). It has been established that the mechanism whereby TGF-beta 1 inhibits cell growth does not interfere with the triggering of early mitogenic signal transduction mechanisms. Phospholipase C-catalyzed hydrolysis of phosphatidylcholine (PC) is a relatively late step in the cascade activated by growth factors. Therefore, conceivably activation of phospholipase C-catalyzed hydrolysis of PC could be the target of TGF-beta 1 action. In the study reported here, we demonstrate that TGF-beta 1 inhibits the coupling of ras p21 to the activation of PC hydrolysis, which appears to be critical for the antiproliferative effects of TGF-beta 1. |
| DOI | 10.1128/mcb.12.1.302-308.1992 |
| Alternate Journal | Mol Cell Biol |
| PubMed ID | 1309592 |
| PubMed Central ID | PMC364110 |
Related Faculty:
Jorge Moscat, Ph.D. Maria Diaz-Meco Conde, Ph.D.