| Title | PET-avid hepatocellular adenomas: incidental findings associated with HNF1-α mutated lesions. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Lee SYee, T Kingham P, LaGratta MD, Jessurun J, Cherqui D, Jarnagin WR, Kluger MD |
| Journal | HPB (Oxford) |
| Volume | 18 |
| Issue | 1 |
| Pagination | 41-8 |
| Date Published | 2016 Jan |
| ISSN | 1477-2574 |
| Keywords | Adenoma, Liver Cell, Adult, Biomarkers, Tumor, Biopsy, Databases, Factual, Diagnostic Errors, DNA Mutational Analysis, False Positive Reactions, Female, Fluorodeoxyglucose F18, Hepatocyte Nuclear Factor 1-alpha, Humans, Incidental Findings, Liver Neoplasms, Male, Mutation, Positron-Emission Tomography, Predictive Value of Tests, Radiopharmaceuticals, Reproducibility of Results, Retrospective Studies, Tomography, X-Ray Computed |
| Abstract | BACKGROUND: Hepatocellular adenoma (HCA) is the second most common benign liver neoplasm and occurs predominantly in women in their reproductive years. Positron emission tomography (PET) using [18F] fluorodeoxyglucose (FDG) is commonly used in cancer staging, surveillance and evaluation of treatment response. PET-avid HCA are rare and can be falsely interpreted as malignancies. METHODS: A retrospective review of four institutions' database was performed to identify the PET-avid HCAs with clinico-pathological correlation. RESULTS: Nine patients with histological proven PET-avid HCA was identified. Eight out of 9 patients were female with a median age at diagnosis of 44 years. All patients' tumors with available histological subtyping (8/8) were HNF1-α mutated and had no inflammatory changes; 6 out the 9 lesions had prominent (>50%) steatotic changes. CONCLUSION: Hepatocellular adenomas, specifically the HNF1-α subtype, can cause false-positive PET findings when seeking to identify malignancy. Concomitantly, PET-CT may have the potential to identify the HCA histopathologic variant with the lowest malignant and hemorrhagic potential. |
| DOI | 10.1016/j.hpb.2015.07.001 |
| Alternate Journal | HPB (Oxford) |
| PubMed ID | 26776850 |
| PubMed Central ID | PMC4750225 |
| Grant List | P30 CA008748 / CA / NCI NIH HHS / United States |
Related Faculty:
Jose Jessurun, M.D.