Papillary thyroid carcinoma with nodular fasciitis-like stroma: a usual entity with distinctive morphology.

TitlePapillary thyroid carcinoma with nodular fasciitis-like stroma: a usual entity with distinctive morphology.
Publication TypeJournal Article
Year of Publication2015
AuthorsGinter PS, Scognamiglio T
JournalInt J Surg Pathol
Volume23
Issue4
Pagination305-7
Date Published2015 Jun
ISSN1940-2465
KeywordsAdult, Biomarkers, Tumor, Carcinoma, Carcinoma, Papillary, Fasciitis, Female, Humans, Immunohistochemistry, Stromal Cells, Thyroid Cancer, Papillary, Thyroid Neoplasms
Abstract

Papillary thyroid carcinoma (PTC) is a common malignancy with multiple variants, some of which are rarely encountered in routine surgical pathology practice. PTC with exuberant nodular fasciitis-like stroma (PTC-NFS) or PTC with fibromatosis-like stroma (PTC-FMS) is one such variant. We report a case of PTC-NFS, a tumor characterized by an abundant stromal component with an intervening epithelial component with the typical morphologic features of conventional PTC. We review the literature on this rare variant, discuss the importance of a thorough search for epithelial components within any fibroproliferative lesion of the thyroid, and address the diagnostic difficulties created by the tumor's extensive stromal component.

DOI10.1177/1066896915570362
Alternate JournalInt J Surg Pathol
PubMed ID25663334
Related Faculty: 
Theresa Scognamiglio, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700