| Title | p27 and Barrett's esophagus: a review*. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Ellis FH, Loda M |
| Journal | Dis Esophagus |
| Volume | 17 |
| Issue | 2 |
| Pagination | 113-7 |
| Date Published | 2004 |
| ISSN | 1120-8694 |
| Keywords | Adenocarcinoma, Animals, Barrett Esophagus, Biomarkers, Tumor, Cell Cycle Proteins, Cell Transformation, Neoplastic, Cyclin-Dependent Kinase Inhibitor p27, Cyclooxygenase 2, Disease Models, Animal, Esophageal Neoplasms, Esophagus, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Humans, Membrane Proteins, Mice, Mucous Membrane, Mutation, Prostaglandin-Endoperoxide Synthases, Rats, Tumor Suppressor Proteins |
| Abstract | The rising prevalence of Barrett's esophagus and Barrett's associated adenocarcinoma in the Western world has stimulated increasing interest in this disease. This has resulted in a plethora of articles concerning its molecular biology, but the tumor suppressor gene, p27, has received little attention. In this article, we review the literature concerning the role of p27 in Barrett's esophagus and its malignant transformation, and we evaluate its possible role as an important clinical biomarker, as well as potential chemopreventive clinical agents aimed at substituting its antitumoral activity. |
| DOI | 10.1111/j.1442-2050.2004.00402.x |
| Alternate Journal | Dis Esophagus |
| PubMed ID | 15230722 |
Related Faculty:
Massimo Loda, M.D.