| Title | Orthotopic Pancreatic Tumor Mouse Models of Liver Metastasis. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Zhang G, Du Y-CNancy |
| Journal | Methods Mol Biol |
| Volume | 1882 |
| Pagination | 309-320 |
| Date Published | 2019 |
| ISSN | 1940-6029 |
| Keywords | Animals, Cell Culture Techniques, Cell Line, Tumor, Culture Media, Conditioned, Humans, Liver, Liver Neoplasms, Mice, Mice, Inbred NOD, Pancreatic Neoplasms, Xenograft Model Antitumor Assays |
| Abstract | The survival from pancreatic cancer is poor because most patients are diagnosed after the cancer has metastasized. Liver is the most common site of pancreatic cancer metastasis. Orthotopic mouse models of liver metastasis by intrasplenically injecting the pancreatic tumor cells are useful in studying the molecular mechanisms of metastasis and evaluating therapeutic regimens. |
| DOI | 10.1007/978-1-4939-8879-2_27 |
| Alternate Journal | Methods Mol Biol |
| PubMed ID | 30378065 |
| PubMed Central ID | PMC6800204 |
| Grant List | R01 CA204916 / CA / NCI NIH HHS / United States |
Related Faculty:
Yi-Chieh (Nancy) Du, Ph.D.