| Title | NF-kappaB activation by protein kinase C isoforms and B-cell function. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Moscat J, Diaz-Meco MT, Rennert P |
| Journal | EMBO Rep |
| Volume | 4 |
| Issue | 1 |
| Pagination | 31-6 |
| Date Published | 2003 Jan |
| ISSN | 1469-221X |
| Keywords | Animals, Apoptosis, B-Lymphocytes, Gene Expression Regulation, Humans, I-kappa B Kinase, Isoenzymes, Macromolecular Substances, Mice, Mice, Knockout, Models, Biological, NF-kappa B, Phosphorylation, Protein Kinase C, Protein Processing, Post-Translational, Protein Subunits, Protein-Serine-Threonine Kinases, Receptors, Antigen, B-Cell, Signal Transduction, Transcription, Genetic |
| Abstract | B cells are essential to the immune response in health and disease. Results from knockout (KO) mice for different members of the nuclear factor-kappaB (NF-kappaB) family have highlighted the importance of this transcription factor in B cell development and function. The recent generation of additional KO mice for adapters and kinases implicated in NF-kappaB activation, including several protein kinase C isoforms, has provided new insights into the roles of these proteins in B cell signalling. These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-kappaB. |
| DOI | 10.1038/sj.embor.embor704 |
| Alternate Journal | EMBO Rep |
| PubMed ID | 12524517 |
| PubMed Central ID | PMC1315804 |
Related Faculty:
Jorge Moscat, Ph.D. Maria Diaz-Meco Conde, Ph.D.