N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma).

TitleN-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma).
Publication TypeJournal Article
Year of Publication1993
AuthorsFabbretti G, Valenti C, Loda M, Brisigotti M, Cozzutto C, Tonini GP, Callea F
JournalHum Pathol
Date Published1993 Mar
KeywordsChild, Preschool, DNA, Neoplasm, Female, Ganglioneuroma, Gene Amplification, Gene Expression Regulation, Neoplastic, Genes, myc, Humans, Male, Neuroblastoma, Nucleic Acid Hybridization, Prognosis, Proto-Oncogene Proteins c-myc

Using nucleic acid analysis and in situ hybridization we have demonstrated N-myc amplification and expression in two children with a localized (stages I and II) stroma-rich neuroblastoma (NB) (ganglioneuroblastoma). The phenomenon was observed in both undifferentiated and mature ganglion-like cells. The two children are alive and disease-free without any treatment after 16 and 17 months. These observations suggest that morphologic differentiation in NB in vivo is not necessarily followed by a decrease in N-myc expression. Moreover, N-myc amplification does not represent an adverse prognostic factor. In contrast with what happens in undifferentiated NB, N-myc amplification does not have an adverse effect on prognosis when occurring in localized (stages I and II), stroma-rich NB with a favorable histology.

Alternate JournalHum Pathol
PubMed ID8454274
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