A multidisciplinary management algorithm for brain metastases.

TitleA multidisciplinary management algorithm for brain metastases.
Publication TypeJournal Article
Year of Publication2022
AuthorsRamos A, Giantini-Larsen A, Pannullo SC, Brandmaier A, Knisely J, Magge R, Wilcox JA, Pavlick AC, Ma B, Pisapia D, Ashamalla H, Ramakrishna R
JournalNeurooncol Adv
Date Published2022 Jan-Dec

The incidence of brain metastases continues to present a management issue despite the advent of improved systemic control and overall survival. While the management of oligometastatic disease (ie, 1-4 brain metastases) with surgery and radiation has become fairly straightforward in the era of radiosurgery, the management of patients with multiple metastatic brain lesions can be challenging. Here we review the available evidence and provide a multidisciplinary management algorithm for brain metastases that incorporates the latest advances in surgery, radiation therapy, and systemic therapy while taking into account the latest in precision medicine-guided therapies. In particular, we argue that whole-brain radiation therapy can likely be omitted in most patients as up-front therapy.

Alternate JournalNeurooncol Adv
PubMed ID36532509
PubMed Central IDPMC9749403
Grant ListP30 CA008748 / CA / NCI NIH HHS / United States
Related Faculty: 
David Pisapia, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700