| Title | A Missing Link to Vitamin B Metabolism. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Reid MA, Paik J, Locasale JW |
| Journal | Cell |
| Volume | 171 |
| Issue | 4 |
| Pagination | 736-737 |
| Date Published | 2017 11 02 |
| ISSN | 1097-4172 |
| Keywords | Gene Knockout Techniques, Humans, Succinates, Vitamin B 12, Vitamins |
| Abstract | Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B metabolism and the immunomodulatory metabolite, itaconate. |
| DOI | 10.1016/j.cell.2017.10.030 |
| Alternate Journal | Cell |
| PubMed ID | 29100069 |
| Grant List | S10 OD018164 / OD / NIH HHS / United States |
Related Faculty:
Ji-Hye Paik, Ph.D.