Metabolic circuits in neural stem cells.

TitleMetabolic circuits in neural stem cells.
Publication TypeJournal Article
Year of Publication2014
AuthorsKim D-Y, Rhee I, Paik J
JournalCell Mol Life Sci
Date Published2014 Nov
KeywordsAnimals, Brain, Cell Lineage, Cognition, Cognition Disorders, Epigenesis, Genetic, Gene Expression Regulation, Humans, Hypoxia, Inflammation, Lipids, Neural Stem Cells, Neurodegenerative Diseases, Neurogenesis, Regeneration

Metabolic activity indicative of cellular demand is emerging as a key player in cell fate decision. Numerous studies have demonstrated that diverse metabolic pathways have a critical role in the control of the proliferation, differentiation and quiescence of stem cells. The identification of neural stem/progenitor cells (NSPCs) and the characterization of their development and fate decision process have provided insight into the regenerative potential of the adult brain. As a result, the potential of NSPCs in cell replacement therapies for neurological diseases is rapidly growing. The aim of this review is to discuss the recent findings on the crosstalk among key regulators of NSPC development and the metabolic regulation crucial for the function and cell fate decisions of NSPCs. Fundamental understanding of the metabolic circuits in NSPCs may help to provide novel approaches for reactivating neurogenesis to treat degenerative brain conditions and cognitive decline.

Alternate JournalCell Mol Life Sci
PubMed ID25037158
PubMed Central IDPMC4394599
Grant ListR01 AG048284 / AG / NIA NIH HHS / United States
Related Faculty: 
Ji-Hye Paik, Ph.D.

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