| Title | A matter of access. Nucleosome disassembly from gene promoters is the central goal of transcriptional activators. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Hu Z, Chen K, Li W, Tyler JK |
| Journal | Transcription |
| Volume | 5 |
| Issue | 2 |
| Pagination | e29355 |
| Date Published | 2014 |
| ISSN | 2154-1272 |
| Keywords | DNA-Binding Proteins, Fungal Proteins, Nucleosomes, Promoter Regions, Genetic, Transcriptional Activation, Yeasts |
| Abstract | The mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA. |
| DOI | 10.4161/trns.29355 |
| Alternate Journal | Transcription |
| PubMed ID | 25764221 |
| PubMed Central ID | PMC4215176 |
| Grant List | R01HG007538 / HG / NHGRI NIH HHS / United States R01 CA095641 / CA / NCI NIH HHS / United States R01GM64475 / GM / NIGMS NIH HHS / United States R01 GM064475 / GM / NIGMS NIH HHS / United States R01CA95641 / CA / NCI NIH HHS / United States R01 HG007538 / HG / NHGRI NIH HHS / United States |
Related Faculty:
Jessica K. Tyler, Ph.D.