Lipoprotein and albumin accumulation in reendothelialized and deendothelialized aorta.

TitleLipoprotein and albumin accumulation in reendothelialized and deendothelialized aorta.
Publication TypeJournal Article
Year of Publication1984
AuthorsFalcone DJ, Hajjar DP, Minick CR
JournalAm J Pathol
Date Published1984 Jan
KeywordsAnimals, Aorta, Biological Transport, Endothelium, Female, Iodine Radioisotopes, Lipoproteins, LDL, Rabbits, Regeneration, Serum Albumin, Serum Albumin, Radio-Iodinated

Although arterial injury is believed to be an important factor in the pathogenesis of atherosclerosis, little is known about lipoprotein accumulation in the injured arterial wall. In experiments reported here, the authors quantitated the accumulation of iodinated lipoprotein and albumin in reendothelialized and deendothelialized rabbit aorta. Results indicate that over the experimental period, insudated lipoprotein but not albumin is retained in the reendothelialized aorta. Neither lipoprotein nor albumin was retained in the adjacent persistently deendothelialized aorta. Findings are consistent with the hypothesis that sequestration of lipoprotein in reendothelialized artery is one mechanism by which lipid accumulates in these areas.

Alternate JournalAm J Pathol
PubMed ID6691410
PubMed Central IDPMC1900385
Grant List5-TH32 HL-07423 / HL / NHLBI NIH HHS / United States
HL-18828 / HL / NHLBI NIH HHS / United States
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Domenick J. Falcone, Ph.D.

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