| Title | Kidney tubular toxicity of maintenance pemetrexed therapy. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Glezerman IG, M Pietanza C, Miller V, Seshan SV |
| Journal | Am J Kidney Dis |
| Volume | 58 |
| Issue | 5 |
| Pagination | 817-20 |
| Date Published | 2011 Nov |
| ISSN | 1523-6838 |
| Keywords | Aged, Antimetabolites, Antineoplastic, Female, Glutamates, Guanine, Humans, Kidney Diseases, Kidney Tubules, Male, Middle Aged, Pemetrexed |
| Abstract | Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitial injury with tubular simplification, shrinkage, loss of brush border, and tubular atrophy in a more advanced case. Kidney function remained impaired, but stable, after discontinuation of pemetrexed therapy in all cases. |
| DOI | 10.1053/j.ajkd.2011.04.030 |
| Alternate Journal | Am J Kidney Dis |
| PubMed ID | 21849225 |
Related Faculty:
Surya V. Seshan, M.D.