| Title | Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Mesri EA, Cesarman E |
| Journal | Cell Host Microbe |
| Volume | 10 |
| Issue | 6 |
| Pagination | 529-31 |
| Date Published | 2011 Dec 15 |
| ISSN | 1934-6069 |
| Abstract | Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to-mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis. |
| DOI | 10.1016/j.chom.2011.11.008 |
| Alternate Journal | Cell Host Microbe |
| PubMed ID | 22177556 |
Related Faculty:
Ethel Cesarman, M.D., Ph.D.