Intraductal Carcinoma of the Prostate: A Risk for Rapid Recurrence.

TitleIntraductal Carcinoma of the Prostate: A Risk for Rapid Recurrence.
Publication TypeJournal Article
Year of Publication2017
AuthorsDinerman BF, Bernstein AN, Khani F, Hu JC
JournalUrology
Volume105
Paginatione1-e2
Date Published2017 Jul
ISSN1527-9995
KeywordsCarcinoma, Ductal, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasm Recurrence, Local, Prostatic Neoplasms
Abstract

Intraductal carcinoma of the prostate (IDC-P), recently defined by the World Health Organization in 2016, is a distinct histologic entity associated with an aggressive clinical course, including increased risk of biochemical recurrence, metastasis, and mortality. Differential diagnosis includes intraductal spread of urothelial carcinoma, prostatic ductal carcinoma, and high-grade prostatic intraepithelial neoplasia. BRCA mutations are associated with an increased risk of IDC-P. The presence of IDC-P on initial biopsy or radical prostatectomy should trigger aggressive treatment and should be considered a contraindication to active surveillance, regardless of tumor volume.

DOI10.1016/j.urology.2017.03.030
Alternate JournalUrology
PubMed ID28363741
Related Faculty: 
Francesca Khani, M.D.

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