| Title | Intracellular Ca2+ requirements for zymosan-stimulated phosphoinositide hydrolysis in mouse peritoneal macrophages. |
| Publication Type | Journal Article |
| Year of Publication | 1986 |
| Authors | Moscat J, Aracil M, Diez E, Balsinde J, P Barreno G, Municio AM |
| Journal | Biochem Biophys Res Commun |
| Volume | 134 |
| Issue | 1 |
| Pagination | 367-71 |
| Date Published | 1986 Jan 14 |
| ISSN | 0006-291X |
| Keywords | Animals, Arachidonic Acid, Arachidonic Acids, Calcimycin, Calcium, Catechols, Enzyme Activation, Indomethacin, Macrophages, Male, Masoprocol, Mice, Phosphatidylinositols, Time Factors, Type C Phospholipases, Zymosan |
| Abstract | The phosphatidylinositol cycle has been demonstrated to be involved in the control of Ca2+ cytosolic levels in several cellular types. The Ca2+ requirements of phospholipase C activity and the described stimulation of phosphoinositide hydrolysis by Ca2+ ionophores make unclear the relationship between phosphatidylinositol cycle and Ca2+ mobilization. The results reported here suggest that intracellular Ca2+ is necessary for zymosan-stimulated phospholipase C activation in macrophages. |
| DOI | 10.1016/0006-291x(86)90572-3 |
| Alternate Journal | Biochem Biophys Res Commun |
| PubMed ID | 3004439 |
Related Faculty:
Jorge Moscat, Ph.D.