|Title||Intracellular Ca2+ requirements for zymosan-stimulated phosphoinositide hydrolysis in mouse peritoneal macrophages.|
|Publication Type||Journal Article|
|Year of Publication||1986|
|Authors||Moscat J, Aracil M, Diez E, Balsinde J, P Barreno G, Municio AM|
|Journal||Biochem Biophys Res Commun|
|Date Published||1986 Jan 14|
|Keywords||Animals, Arachidonic Acid, Arachidonic Acids, Calcimycin, Calcium, Catechols, Enzyme Activation, Indomethacin, Macrophages, Male, Masoprocol, Mice, Phosphatidylinositols, Time Factors, Type C Phospholipases, Zymosan|
The phosphatidylinositol cycle has been demonstrated to be involved in the control of Ca2+ cytosolic levels in several cellular types. The Ca2+ requirements of phospholipase C activity and the described stimulation of phosphoinositide hydrolysis by Ca2+ ionophores make unclear the relationship between phosphatidylinositol cycle and Ca2+ mobilization. The results reported here suggest that intracellular Ca2+ is necessary for zymosan-stimulated phospholipase C activation in macrophages.
|Alternate Journal||Biochem Biophys Res Commun|
Jorge Moscat, Ph.D.