Index Case of Cutaneous Follicular Mycosis Fungoides With Central Nervous System Involvement and Review of Literature.

TitleIndex Case of Cutaneous Follicular Mycosis Fungoides With Central Nervous System Involvement and Review of Literature.
Publication TypeJournal Article
Year of Publication2018
AuthorsNguyen GHuong, Mohler A, Leppert M, Parra C, Zeng Y-P, Prok L, Schowinsky J, Magro CM, Pacheco T, Ney D
JournalAm J Dermatopathol
Volume40
Issue3
Pagination185-190
Date Published2018 Mar
ISSN1533-0311
KeywordsBrain Neoplasms, Fatal Outcome, Humans, Male, Middle Aged, Mycosis Fungoides, Skin Neoplasms
Abstract

Central nervous system involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages of the disease. We describe a patient with early-stage follicular MF who presented with changes in mental status. Despite an initial diagnosis of vasculitis based on clinical and brain biopsy results, the postmortem examination revealed extensive infiltration of MF cells throughout the brain with leptomeningeal involvement. This case in addition to the accompanied review of literature illustrates the importance of the awareness of central nervous system involvement by MF and highlights the need for an urgent neurologic evaluation in patients with a history of MF now presenting with neurologic signs or symptoms.

DOI10.1097/DAD.0000000000000955
Alternate JournalAm J Dermatopathol
PubMed ID29470304
Related Faculty: 
Cynthia M. Magro, M.D.

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