Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women.

TitleIncreased trunk fat is associated with altered gene expression in breast tissue of normal weight women.
Publication TypeJournal Article
Year of Publication2022
AuthorsCho BAngela, Iyengar NM, Zhou XKathy, Mendieta H, Winston L, Falcone DJ, Landa J, Morrow M, Dannenberg AJ
JournalNPJ Breast Cancer
Volume8
Issue1
Pagination15
Date Published2022 Jan 27
ISSN2374-4677
Abstract

Increased trunk fat is associated with an elevated risk of breast cancer in normal-weight postmenopausal women. The main objective of this study was to determine whether levels of trunk fat are associated with changes in breast gene expression in normal-weight women. Non-tumorous breast tissue was collected from 32 normal BMI women who underwent mastectomy for breast cancer risk reduction or treatment. Body composition was measured by dual-energy x-ray absorptiometry. High levels of trunk fat were associated with a large number of differentially expressed genes and changes in multiple pathways and processes potentially linked to breast cancer pathogenesis. High levels of trunk fat were also associated with an elevated immune score and increased levels of leptin, CCL2, VEGF-C, IL6, and aromatase. Collectively, these results help to explain why high levels of trunk fat are associated with an increased risk of breast cancer in normal BMI women.

DOI10.1038/s41523-021-00369-8
Alternate JournalNPJ Breast Cancer
PubMed ID35087024
PubMed Central IDPMC8795267
Grant ListP30 CA008748 / CA / NCI NIH HHS / United States
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Domenick J. Falcone, Ph.D.

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