Impact of Consensus Definitions on Identification of Glomerular Lesions by Light and Electron Microscopy.

TitleImpact of Consensus Definitions on Identification of Glomerular Lesions by Light and Electron Microscopy.
Publication TypeJournal Article
Year of Publication2022
AuthorsHaas M, Mirocha J, Amann K, Bajema IM, Barisoni L, Becker JUlrich, J Jennette C, Joh K, Ljubanovic DGalesic, Roberts ISD, Roelofs JJ, Sethi S, Suarez R, Zeng C, Seshan SV
JournalKidney Int Rep
Date Published2022 Jan

INTRODUCTION: In 2020, a working group of 13 renal pathologists published consensus definitions for 47 individual glomerular lesions found on light microscopy (LM) and 47 glomerular lesions and 9 normal structures found on electron microscopy (EM).

METHODS: To test the impact of these definitions on identification of these lesions and structures, 2 surveys were circulated to all members of the Renal Pathology Society (RPS), each having 32 images (19 LM, 13 EM) and accompanying questions with 5 multiple-choice answers, one being the consensus choice of the working group. The first survey (survey 1 [S1]), answered by 297 RPS members, was sent in September 2020, before publication of the consensus definitions. The second (survey 2 [S2]), with images of the same lesions and structures (but not the same images) and the same questions and multiple choices in different order, was sent in April 2020, 5 months after the publication of the definitions.

RESULTS: S2 was taken by 181 RPS members; 64% also took S1 and 61% reported having read the definitions paper (def. paper). Mean agreement with the consensus answers increased modestly between the 2 surveys (65.2% vs. 72.0%, P = 0.097); the increase was greater and significant when only respondents to S2 who read the def. paper were considered (65.2% vs. 74.8%, P = 0.026). Furthermore, in S2 agreement with consensus answers was greater among respondents who read this paper versus those who did not (66.9% vs. 74.8%, P < 0.0001).

CONCLUSIONS: Publication of the consensus definitions modestly improved interobserver agreement in identification of glomerular lesions.

Alternate JournalKidney Int Rep
PubMed ID35005316
PubMed Central IDPMC8720667
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